Forkhead box protein H1 (FOXH1)

About Forkhead box protein H1

Forkhead box protein H1 (FOXH1) is a protein from Homo sapiens identified by UniProt accession O75593, 365 residues long. MolForge cross-references it against 0 known binders and 231 disease associations.

Target properties

Protein name	Forkhead box protein H1
UniProt accession	O75593
Gene	FOXH1
Organism	Homo sapiens
Length	365 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (231)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
Conotruncal defect · score 0.40
alobar holoprosencephaly · score 0.38
microform holoprosencephaly · score 0.38
semilobar holoprosencephaly · score 0.37
lobar holoprosencephaly · score 0.37
septopreoptic holoprosencephaly · score 0.37
midline interhemispheric variant of holoprosencephaly · score 0.37
holoprosencephaly · score 0.22
genetic disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75593-F1	alphafold	PREDICTED	61.75	—

Amino-acid sequence (365 residues)

MGPCSGSRLG PPEAESPSQP PKRRKKRYLR HDKPPYTYLA MIALVIQAAP SRRLKLAQII RQVQAVFPFF REDYEGWKDS IRHNLSSNRC FRKVPKDPAK PQAKGNFWAV DVSLIPAEAL RLQNTALCRR WQNGGARGAF AKDLGPYVLH GRPYRPPSPP PPPSEGFSIK SLLGGSGEGA PWPGLAPQSS PVPAGTGNSG EEAVPTPPLP SSERPLWPLC PLPGPTRVEG ETVQGGAIGP STLSPEPRAW PLHLLQGTAV PGGRSSGGHR ASLWGQLPTS YLPIYTPNVV MPLAPPPTSC PQCPSTSPAY WGVAPETRGP PGLLCDLDAL FQGVPPNKSI YDVWVSHPRD LAAPGPGWLL SWCSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards