About 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (GCAT) is a protein
from Homo sapiens identified by UniProt accession
O75600, 419 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial |
|---|
| UniProt accession | O75600 |
|---|
| Gene | GCAT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 419 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (62)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.26
- erythrocyte count · score 0.23
- sex hormone-binding globulin measurement · score 0.22
- systolic blood pressure · score 0.21
- cystatin C measurement · score 0.19
- hip bone size · score 0.15
- intraocular pressure measurement · score 0.14
- serum albumin measurement · score 0.13
- cognitive function measurement · score 0.13
- red blood cell density measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75600-F1 | alphafold | PREDICTED | 93.40 | — |
Amino-acid sequence (419 residues)
MWPGNAWRAA LFWVPRGRRA QSALAQLRGI LEGELEGIRG AGTWKSERVI TSRQGPHIRV DGVSGGILNF CANNYLGLSS HPEVIQAGLQ ALEEFGAGLS SVRFICGTQS IHKNLEAKIA RFHQREDAIL YPSCYDANAG LFEALLTPED AVLSDELNHA SIIDGIRLCK AHKYRYRHLD MADLEAKLQE AQKHRLRLVA TDGAFSMDGD IAPLQEICCL ASRYGALVFM DECHATGFLG PTGRGTDELL GVMDQVTIIN STLGKALGGA SGGYTTGPGP LVSLLRQRAR PYLFSNSLPP AVVGCASKAL DLLMGSNTIV QSMAAKTQRF RSKMEAAGFT ISGASHPICP VMLGDARLAS RMADDMLKRG IFVIGFSYPV VPKGKARIRV QISAVHSEED IDRCVEAFVE VGRLHGALP
Explore 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets