About Chorion-specific transcription factor GCMb
Chorion-specific transcription factor GCMb (GCM2) is a protein
from Homo sapiens identified by UniProt accession
O75603, 506 residues long.
MolForge cross-references it against 0 known binders and
112 disease associations.
Target properties
| Protein name | Chorion-specific transcription factor GCMb |
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| UniProt accession | O75603 |
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| Gene | GCM2 |
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| Organism | Homo sapiens |
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| Length | 506 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (112)
Diseases linked to this target (Open Targets).
- hypoparathyroidism, familial isolated, 2 · score 0.71
- hyperparathyroidism 4 · score 0.69
- familial hypoparathyroidism · score 0.60
- neurodegenerative disease · score 0.53
- Familial isolated hypoparathyroidism · score 0.50
- calcium measurement · score 0.46
- familial isolated hyperparathyroidism · score 0.39
- familial isolated hypoparathyroidism due to agenesis of parathyroid gland · score 0.39
- hyperparathyroidism · score 0.29
- benign neoplasm of parathyroid gland · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75603-F1 | alphafold | PREDICTED | 58.49 | — |
Amino-acid sequence (506 residues)
MPAAAVQEAV GVCSYGMQLS WDINDPQMPQ ELALFDQFRE WPDGYVRFIY SSDEKKAQRH LSGWAMRNTN NHNGHILKKS CLGVVVCTQA CTLPDGSRLQ LRPAICDKAR LKQQKKACPN CHSALELIPC RGHSGYPVTN FWRLDGNAIF FQAKGVHDHP RPESKSETEA RRSAIKRQMA SFYQPQKKRI RESEAEENQD SSGHFSNIPP LENPEDFDIV TETSFPIPGQ PCPSFPKSDV YKATCDLATF QGDKMPPFQK YSSPRIYLPR PPCSYELANP GYTNSSPYPT LYKDSTSIPN DTDWVHLNTL QCNVNSYSSY ERSFDFTNKQ HGWKPALGKP SLVERTNHGQ FQAMATRPYY NPELPCRYLT TPPPGAPALQ TVITTTTKVS YQAYQPPAMK YSDSVREVKS LSSCNYAPED TGMSVYPEPW GPPVTVTRAA SPSGPPPMKI AGDCRAIRPT VAIPHEPVSS RTDEAETWDV CLSGLGSAVS YSDRVGPFFT YNNEDF
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