About Ubiquitin carboxyl-terminal hydrolase 2
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) is a protein
from Homo sapiens identified by UniProt accession
O75604, 605 residues long.
MolForge cross-references it against 0 known binders and
223 disease associations.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 2 |
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| UniProt accession | O75604 |
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| Gene | USP2 |
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| Organism | Homo sapiens |
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| Length | 605 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (223)
Diseases linked to this target (Open Targets).
- refractive error measurement · score 0.35
- urate measurement · score 0.31
- refractive error · score 0.29
- glioblastoma multiforme · score 0.28
- breast adenocarcinoma · score 0.27
- ovarian cancer · score 0.27
- neurodegenerative disease · score 0.24
- squamous cell lung carcinoma · score 0.23
- endometrial cancer · score 0.23
- uric acid measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75604-F1 | alphafold | PREDICTED | 68.13 | — |
Amino-acid sequence (605 residues)
MSQLSSTLKR YTESARYTDA HYAKSGYGAY TPSSYGANLA ASLLEKEKLG FKPVPTSSFL TRPRTYGPSS LLDYDRGRPL LRPDITGGGK RAESQTRGTE RPLGSGLSGG SGFPYGVTNN CLSYLPINAY DQGVTLTQKL DSQSDLARDF SSLRTSDSYR IDPRNLGRSP MLARTRKELC TLQGLYQTAS CPEYLVDYLE NYGRKGSASQ VPSQAPPSRV PEIISPTYRP IGRYTLWETG KGQAPGPSRS SSPGRDGMNS KSAQGLAGLR NLGNTCFMNS ILQCLSNTRE LRDYCLQRLY MRDLHHGSNA HTALVEEFAK LIQTIWTSSP NDVVSPSEFK TQIQRYAPRF VGYNQQDAQE FLRFLLDGLH NEVNRVTLRP KSNPENLDHL PDDEKGRQMW RKYLEREDSR IGDLFVGQLK SSLTCTDCGY CSTVFDPFWD LSLPIAKRGY PEVTLMDCMR LFTKEDVLDG DEKPTCCRCR GRKRCIKKFS IQRFPKILVL HLKRFSESRI RTSKLTTFVN FPLRDLDLRE FASENTNHAV YNLYAVSNHS GTTMGGHYTA YCRSPGTGEW HTFNDSSVTP MSSSQVRTSD AYLLFYELAS PPSRM
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