Left-right determination factor 1 (LEFTY1)

About Left-right determination factor 1

Left-right determination factor 1 (LEFTY1) is a protein from Homo sapiens identified by UniProt accession O75610, 366 residues long. MolForge cross-references it against 0 known binders and 119 disease associations.

Target properties

Protein name	Left-right determination factor 1
UniProt accession	O75610
Gene	LEFTY1
Organism	Homo sapiens
Length	366 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (119)

Diseases linked to this target (Open Targets).

appendicular lean mass · score 0.09
Heterotaxia · score 0.08
Barrett's esophagus · score 0.08
visceral heterotaxy · score 0.07
heterotaxy, visceral, 12, autosomal · score 0.07
scimitar syndrome · score 0.06
congenital heart disease · score 0.06
right atrial isomerism · score 0.06
tricuspid atresia · score 0.06
congenital heart defects, multiple types, 6 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75610-F1	alphafold	PREDICTED	78.43	—

Amino-acid sequence (366 residues)

MQPLWLCWAL WVLPLASPGA ALTGEQLLGS LLRQLQLKEV PTLDRADMEE LVIPTHVRAQ YVALLQRSHG DRSRGKRFSQ SFREVAGRFL ALEASTHLLV FGMEQRLPPN SELVQAVLRL FQEPVPKAAL HRHGRLSPRS ARARVTVEWL RVRDDGSNRT SLIDSRLVSV HESGWKAFDV TEAVNFWQQL SRPRQPLLLQ VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL DLGDYGAQGD CDPEAPMTEG TRCCRQEMYI DLQGMKWAEN WVLEPPGFLA YECVGTCRQP PEALAFKWPF LGPRQCIASE TDSLPMIVSI KEGGRTRPQV VSLPNMRVQK CSCASDGALV PRRLQP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards