About Death effector domain-containing protein
Death effector domain-containing protein (DEDD) is a protein
from Homo sapiens identified by UniProt accession
O75618, 318 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | Death effector domain-containing protein |
|---|
| UniProt accession | O75618 |
|---|
| Gene | DEDD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 318 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (18)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.14
- Alzheimer disease · score 0.09
- family history of Alzheimer’s disease · score 0.09
- appendicular lean mass · score 0.08
- leukocyte count · score 0.04
- serum gamma-glutamyl transferase measurement · score 0.03
- mean corpuscular hemoglobin concentration · score 0.02
- triple-negative breast cancer · score 0.01
- neoplasm · score 0.01
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75618-F1 | alphafold | PREDICTED | 77.24 | — |
Amino-acid sequence (318 residues)
MAGLKRRASQ VWPEEHGEQE HGLYSLHRMF DIVGTHLTHR DVRVLSFLFV DVIDDHERGL IRNGRDFLLA LERQGRCDES NFRQVLQLLR IITRHDLLPY VTLKRRRAVC PDLVDKYLEE TSIRYVTPRA LSDPEPRPPQ PSKTVPPHYP VVCCPTSGPQ MCSKRPARGR ATLGSQRKRR KSVTPDPKEK QTCDIRLRVR AEYCQHETAL QGNVFSNKQD PLERQFERFN QANTILKSRD LGSIICDIKF SELTYLDAFW RDYINGSLLE ALKGVFITDS LKQAVGHEAI KLLVNVDEED YELGRQKLLR NLMLQALP
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