About Uroplakin-3a
Uroplakin-3a (UPK3A) is a protein
from Homo sapiens identified by UniProt accession
O75631, 287 residues long.
MolForge cross-references it against 0 known binders and
174 disease associations.
Target properties
| Protein name | Uroplakin-3a |
|---|
| UniProt accession | O75631 |
|---|
| Gene | UPK3A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 287 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (174)
Diseases linked to this target (Open Targets).
- renal agenesis, unilateral · score 0.37
- renal hypodysplasia/aplasia 1 · score 0.20
- congenital anomalies of kidney and urinary tract 1 · score 0.15
- bacterial urinary tract infection · score 0.07
- benign prostatic hyperplasia · score 0.07
- familial juvenile hyperuricemic nephropathy type 1 · score 0.06
- body height · score 0.06
- Ochoa syndrome · score 0.06
- prostate carcinoma · score 0.06
- multicystic dysplastic kidney · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75631-F1 | alphafold | PREDICTED | 78.59 | — |
Amino-acid sequence (287 residues)
MPPLWALLAL GCLRFGSAVN LQPQLASVTF ATNNPTLTTV ALEKPLCMFD SKEALTGTHE VYLYVLVDSA ISRNASVQDS TNTPLGSTFL QTEGGRTGPY KAVAFDLIPC SDLPSLDAIG DVSKASQILN AYLVRVGANG TCLWDPNFQG LCNAPLSAAT EYRFKYVLVN MSTGLVEDQT LWSDPIRTNQ LTPYSTIDTW PGRRSGGMIV ITSILGSLPF FLLVGFAGAI ALSLVDMGSS DGETTHDSQI TQEAVPKSLG ASESSYTSVN RGPPLDRAEV YSSKLQD
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