About Ficolin-3
Ficolin-3 (FCN3) is a protein
from Homo sapiens identified by UniProt accession
O75636, 299 residues long.
MolForge cross-references it against 0 known binders and
148 disease associations.
Target properties
| Protein name | Ficolin-3 |
|---|
| UniProt accession | O75636 |
|---|
| Gene | FCN3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 299 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (148)
Diseases linked to this target (Open Targets).
- immunodeficiency due to ficolin3 deficiency · score 0.61
- rheumatic heart disease · score 0.22
- hepatocellular carcinoma · score 0.13
- cutaneous melanoma · score 0.12
- Microcephaly · score 0.11
- Systemic lupus erythematosus · score 0.09
- neoplasm · score 0.09
- leprosy · score 0.08
- pulmonary tuberculosis · score 0.07
- cancer · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75636-F1 | alphafold | PREDICTED | 86.50 | — |
Amino-acid sequence (299 residues)
MDLLWILPSL WLLLLGGPAC LKTQEHPSCP GPRELEASKV VLLPSCPGAP GSPGEKGAPG PQGPPGPPGK MGPKGEPGDP VNLLRCQEGP RNCRELLSQG ATLSGWYHLC LPEGRALPVF CDMDTEGGGW LVFQRRQDGS VDFFRSWSSY RAGFGNQESE FWLGNENLHQ LTLQGNWELR VELEDFNGNR TFAHYATFRL LGEVDHYQLA LGKFSEGTAG DSLSLHSGRP FTTYDADHDS SNSNCAVIVH GAWWYASCYR SNLNGRYAVS EAAAHKYGID WASGRGVGHP YRRVRMMLR
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