About Mitochondrial tRNA-specific 2-thiouridylase 1
Mitochondrial tRNA-specific 2-thiouridylase 1 (TRMU) is a protein
from Homo sapiens identified by UniProt accession
O75648, 421 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | Mitochondrial tRNA-specific 2-thiouridylase 1 |
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| UniProt accession | O75648 |
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| Gene | TRMU |
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| Organism | Homo sapiens |
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| Length | 421 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (48)
Diseases linked to this target (Open Targets).
- acute infantile liver failure due to synthesis defect of mtDNA-encoded proteins · score 0.78
- Mitochondrial non-syndromic sensorineural deafness with susceptibility to aminoglycoside exposure · score 0.72
- deafness, aminoglycoside-induced · score 0.60
- neurodegenerative disease · score 0.49
- genetic disorder · score 0.47
- Mitochondrial non-syndromic sensorineural deafness · score 0.37
- mitochondrial myopathy with reversible cytochrome C oxidase deficiency · score 0.37
- low density lipoprotein cholesterol measurement · score 0.22
- Leigh syndrome · score 0.18
- eosinophil count · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75648-F1 | alphafold | PREDICTED | 89.38 | — |
Amino-acid sequence (421 residues)
MQALRHVVCA LSGGVDSAVA ALLLRRRGYQ VTGVFMKNWD SLDEHGVCTA DKDCEDAYRV CQILDIPFHQ VSYVKEYWND VFSDFLNEYE KGRTPNPDIV CNKHIKFSCF FHYAVDNLGA DAIATGHYAR TSLEDEEVFE QKHVKKPEGL FRNRFEVRNA VKLLQAADSF KDQTFFLSQV SQDALRRTIF PLGGLTKEFV KKIAAENRLH HVLQKKESMG MCFIGKRNFE HFLLQYLQPR PGHFISIEDN KVLGTHKGWF LYTLGQRANI GGLREPWYVV EKDSVKGDVF VAPRTDHPAL YRDLLRTSRV HWIAEEPPAA LVRDKMMECH FRFRHQMALV PCVLTLNQDG TVWVTAVQAV RALATGQFAV FYKGDECLGS GKILRLGPSA YTLQKGQRRA GMATESPSDS PEDGPGLSPL L
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