Ret finger protein-like 1 (RFPL1)

About Ret finger protein-like 1

Ret finger protein-like 1 (RFPL1) is a protein from Homo sapiens identified by UniProt accession O75677, 317 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	Ret finger protein-like 1
UniProt accession	O75677
Gene	RFPL1
Organism	Homo sapiens
Length	317 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.30
diffuse plaque measurement · score 0.24
aspartate aminotransferase measurement · score 0.21
reticulocyte measurement · score 0.05
hair color · score 0.04
type 2 diabetes mellitus · score 0.03
head and neck squamous cell carcinoma · score 0.00
neoplasm · score 0.00
hepatocellular carcinoma · score 0.00
hematocrit · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75677-F1	alphafold	PREDICTED	84.55	—

Amino-acid sequence (317 residues)

MKRLSLVTTN RLSPHGNFLP LCTFPLAVDM AALFQEASSC PVCSDYLEKP MSLECGCAVC FKCINSLQKE PHGEDLLCCC CSMVSQKNKI RPSWQLERLA SHIKELEPKL KKILQMNPRM RKFQVDMTLD ADTANNFLLI SDDLRSVRSG CITQNRQDLA ERFDVSICIL GSPRFTCGRH YWEVDVGTST EWDLGVCRES VHRKGRIHLT TERGFWTVSL RDGSRLSAST VPLTFLFVDR KLQRVGIFLD MGMQNVSFFD AEGGSHVYTF RSVSAEEPLH LFFAPPSPPN GDKSVLSICP VINPGTTDAP VHPGEAK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards