Ret finger protein-like 2 (RFPL2)

About Ret finger protein-like 2

Ret finger protein-like 2 (RFPL2) is a protein from Homo sapiens identified by UniProt accession O75678, 378 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Ret finger protein-like 2
UniProt accession	O75678
Gene	RFPL2
Organism	Homo sapiens
Length	378 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

docosahexaenoic acid measurement · score 0.09
visual perception measurement · score 0.07
HbA1c measurement · score 0.05
anti-chlamydia trachomatis antibody measurement · score 0.04
urate measurement · score 0.04
type 2 diabetes mellitus · score 0.04
glucose tolerance test · score 0.03
glucagon-like peptide-1 measurement · score 0.03
1,5 anhydroglucitol measurement · score 0.03
hemoglobin A1 measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75678-F1	alphafold	PREDICTED	73.41	—

Amino-acid sequence (378 residues)

MEVAELGFPE TAVSQSRICL CAVLCGHWDF ADMMVIRSLS LIRLEGVEGR DPVGGGNLTN KRPSCAPSPQ DLSAQWKQLE DRGASSRRVD MAALFQEASS CPVCSDYLEK PMSLECGCAV CLKCINSLQK EPHGEDLLCC CSSMVSRKNK IRRNRQLERL ASHIKELEPK LKKILQMNPR MRKFQVDMTL DANTANNFLL ISDDLRSVRS GRIRQNRQDL AERFDVSVCI LGSPRFTCGR HCWEVDVGTS TEWDLGVCRE SVHRKGRIQL TTELGFWTVS LRDGGRLSAT TVPLTFLFVD RKLQRVGIFL DMGMQNVSFF DAESGSHVYT FRSVSAEEPL RPFLAPSVPP NGDQGVLSIC PLMNSGTTDA PVRPGEAK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards