About Ret finger protein-like 3
Ret finger protein-like 3 (RFPL3) is a protein
from Homo sapiens identified by UniProt accession
O75679, 317 residues long.
MolForge cross-references it against 0 known binders and
10 disease associations.
Target properties
| Protein name | Ret finger protein-like 3 |
|---|
| UniProt accession | O75679 |
|---|
| Gene | RFPL3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 317 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (10)
Diseases linked to this target (Open Targets).
- adolescent idiopathic scoliosis · score 0.16
- acne · score 0.09
- neoplasm · score 0.04
- non-small cell lung carcinoma · score 0.04
- lymph node metastatic carcinoma · score 0.02
- Neoplasm of the lung · score 0.01
- cancer · score 0.00
- multiple myeloma · score 0.00
- HIV infection · score 0.00
- HIV-1 infection · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75679-F1 | alphafold | PREDICTED | 85.08 | — |
Amino-acid sequence (317 residues)
MKRLSLVTTN RLSPQGNFLP LCTFPLAVDM AALFQEASSC PVCSDYLEKP MSLECGCTVC LKCINSLQKE PHGEDLLCCC CSMVSQRNKI RPNRQLERLV SHIKELEPKL KKILQMNPRM RKFQVDMTLD ADTANNFLLI SDDLRSVRSG LITQNRQDLA ERFDVSVCIL GSPRFTCGRH YWEVDVGTST EWDLGVCRES VHCKGKIQLT TELGFWTVSL RDGSRLSAST VPLTFLLVDR KLQRVGIFLD MGMQNVSFFD AESGSHVYTF RSVSAEEPLR PFLAPSIPPN GDQGVLSICP LMNSGTTDAP VRPGEAK
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