Surfeit locus protein 6 (SURF6)

About Surfeit locus protein 6

Surfeit locus protein 6 (SURF6) is a protein from Homo sapiens identified by UniProt accession O75683, 361 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	Surfeit locus protein 6
UniProt accession	O75683
Gene	SURF6
Organism	Homo sapiens
Length	361 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
alkaline phosphatase measurement · score 0.16
venous thromboembolism · score 0.09
neutrophil percentage of leukocytes · score 0.07
lymphocyte count · score 0.07
mean platelet volume · score 0.05
Red cell distribution width · score 0.03
e-selectin measurement · score 0.03
a disintegrin and metalloproteinase with thrombospondin motifs 13 measurement · score 0.03
blood protein measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75683-F1	alphafold	PREDICTED	73.84	—

Amino-acid sequence (361 residues)

MASLLAKDAY LQSLAKKICS HSAPEQQART RAGKTQGSET AGPPKKKRKK TQKKFRKREE KAAEHKAKSL GEKSPAASGA RRPEAAKEEA AWASSSAGNP ADGLATEPES VFALDVLRQR LHEKIQEARG QGSAKELSPA ALEKRRRRKQ ERDRKKRKRK ELRAKEKARK AEEATEAQEV VEATPEGACT EPREPPGLIF NKVEVSEDEP ASKAQRRKEK RQRVKGNLTP LTGRNYRQLL ERLQARQSRL DELRGQDEGK AQELEAKMKW TNLLYKAEGV KIRDDERLLQ EALKRKEKRR AQRQRRWEKR TAGVVEKMQQ RQDRRRQNLR RKKAARAERR LLRARKKGRI LPQDLERAGL V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards