Protein phosphatase 1B (PPM1B)

About Protein phosphatase 1B

Protein phosphatase 1B (PPM1B) is a protein from Homo sapiens identified by UniProt accession O75688, 479 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	Protein phosphatase 1B
UniProt accession	O75688
Gene	PPM1B
Organism	Homo sapiens
Length	479 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (57)

Diseases linked to this target (Open Targets).

cancer · score 0.51
body height · score 0.42
appendicular lean mass · score 0.32
lean body mass · score 0.32
FEV/FVC ratio · score 0.31
neurodegenerative disease · score 0.30
BMI-adjusted waist circumference · score 0.26
alcohol consumption measurement · score 0.26
fat body mass · score 0.26
self reported educational attainment · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75688-F1	alphafold	PREDICTED	84.68	—

Amino-acid sequence (479 residues)

MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL EDWSFFAVYD GHAGSRVANY CSTHLLEHIT TNEDFRAAGK SGSALELSVE NVKNGIRTGF LKIDEYMRNF SDLRNGMDRS GSTAVGVMIS PKHIYFINCG DSRAVLYRNG QVCFSTQDHK PCNPREKERI QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFIIL ACDGIWDVMS NEELCEYVKS RLEVSDDLEN VCNWVVDTCL HKGSRDNMSI VLVCFSNAPK VSDEAVKKDS ELDKHLESRV EEIMEKSGEE GMPDLAHVMR ILSAENIPNL PPGGGLAGKR NVIEAVYSRL NPHRESDGAS DEAEESGSQG KLVEALRQMR INHRGNYRQL LEEMLTSYRL AKVEGEESPA EPAATATSSN SDAGNPVTMQ ESHTESESGL AELDSSNEDA GTKMSGEKI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards