Arf-GAP with dual PH domain-containing protein 1…

About Arf-GAP with dual PH domain-containing protein 1

Arf-GAP with dual PH domain-containing protein 1 (ADAP1) is a protein from Homo sapiens identified by UniProt accession O75689, 374 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	Arf-GAP with dual PH domain-containing protein 1
UniProt accession	O75689
Gene	ADAP1
Organism	Homo sapiens
Length	374 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.37
lymphocyte percentage of leukocytes · score 0.34
apolipoprotein A 1 measurement · score 0.31
platelet component distribution width · score 0.23
neurodegenerative disease · score 0.21
high density lipoprotein cholesterol measurement · score 0.21
platelet count · score 0.18
alkaline phosphatase measurement · score 0.16
monocyte count · score 0.15
mean platelet volume · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75689-F1	alphafold	PREDICTED	95.94	—

Amino-acid sequence (374 residues)

MAKERRRAVL ELLQRPGNAR CADCGAPDPD WASYTLGVFI CLSCSGIHRN IPQVSKVKSV RLDAWEEAQV EFMASHGNDA ARARFESKVP SFYYRPTPSD CQLLREQWIR AKYERQEFIY PEKQEPYSAG YREGFLWKRG RDNGQFLSRK FVLTEREGAL KYFNRNDAKE PKAVMKIEHL NATFQPAKIG HPHGLQVTYL KDNSTRNIFI YHEDGKEIVD WFNALRAARF HYLQVAFPGA GDADLVPKLS RNYLKEGYME KTGPKQTEGF RKRWFTMDDR RLMYFKDPLD AFARGEVFIG SKESGYTVLH GFPPSTQGHH WPHGITIVTP DRKFLFACET ESDQREWVAA FQKAVDRPML PQEYAVEAHF KHKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Arf-GAP with dual PH domain-containing protein 1 (ADAP1)