About Keratin-associated protein 5-8
Keratin-associated protein 5-8 (KRTAP5-8) is a protein
from Homo sapiens identified by UniProt accession
O75690, 187 residues long.
MolForge cross-references it against 0 known binders and
11 disease associations.
Target properties
| Protein name | Keratin-associated protein 5-8 |
|---|
| UniProt accession | O75690 |
|---|
| Gene | KRTAP5-8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 187 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (11)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
- low grade glioma · score 0.11
- vitamin D measurement · score 0.05
- protein measurement · score 0.04
- Hodgkins lymphoma · score 0.03
- adolescent idiopathic scoliosis · score 0.03
- neoplasm · score 0.00
- breast cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75690-F1 | alphafold | PREDICTED | 39.04 | — |
Amino-acid sequence (187 residues)
MGCCGCSGGC GSGCGGCGSG CGGCGSSCCV PICCCKPVCC CVPACSCSSC GSCGGSKGGR GSCGGSKGDC GSCGGSKGGC GSCGCSQCSC YKPCCCSSGC GSSCCQSSCC KPCCSQSSCC KPCSCSSGCG SSCCQSSCCK PCCSQSSCCK PCCCSSGCGS SCCQSSCCKP CCSQSSCCVP ICCQCKI
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