About Protein XRP2
Protein XRP2 (RP2) is a protein
from Homo sapiens identified by UniProt accession
O75695, 350 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Protein XRP2 |
|---|
| UniProt accession | O75695 |
|---|
| Gene | RP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 350 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (31)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.75
- Retinal dystrophy · score 0.55
- Leber congenital amaurosis · score 0.44
- cone-rod dystrophy · score 0.34
- Cone rod dystrophy · score 0.34
- Macular dystrophy · score 0.26
- Abnormality of the eye · score 0.26
- genetic disorder · score 0.19
- retinitis pigmentosa 73 · score 0.06
- Sorsby's fundus dystrophy · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75695-F1 | alphafold | PREDICTED | 91.99 | — |
Amino-acid sequence (350 residues)
MGCFFSKRRK ADKESRPENE EERPKQYSWD QREKVDPKDY MFSGLKDETV GRLPGTVAGQ QFLIQDCENC NIYIFDHSAT VTIDDCTNCI IFLGPVKGSV FFRNCRDCKC TLACQQFRVR DCRKLEVFLC CATQPIIESS SNIKFGCFQW YYPELAFQFK DAGLSIFNNT WSNIHDFTPV SGELNWSLLP EDAVVQDYVP IPTTEELKAV RVSTEANRSI VPISRGQRQK SSDESCLVVL FAGDYTIANA RKLIDEMVGK GFFLVQTKEV SMKAEDAQRV FREKAPDFLP LLNKGPVIAL EFNGDGAVEV CQLIVNEIFN GTKMFVSESK ETASGDVDSF YNFADIQMGI
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