About Gap junction beta-3 protein
Gap junction beta-3 protein (GJB3) is a protein
from Homo sapiens identified by UniProt accession
O75712, 270 residues long.
MolForge cross-references it against 0 known binders and
180 disease associations.
Target properties
| Protein name | Gap junction beta-3 protein |
|---|
| UniProt accession | O75712 |
|---|
| Gene | GJB3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 270 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (180)
Diseases linked to this target (Open Targets).
- erythrokeratodermia variabilis · score 0.73
- deafness · score 0.61
- autosomal dominant nonsyndromic hearing loss · score 0.60
- hearing loss, autosomal recessive · score 0.48
- erythrokeratoderma · score 0.37
- hearing loss · score 0.37
- Peripheral neuropathy · score 0.37
- peripheral neuropathy · score 0.37
- neuropathy with hearing impairment · score 0.37
- nonsyndromic deafness · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75712-F1 | alphafold | PREDICTED | 78.37 | — |
Amino-acid sequence (270 residues)
MDWKTLQALL SGVNKYSTAF GRIWLSVVFV FRVLVYVVAA ERVWGDEQKD FDCNTKQPGC TNVCYDNYFP ISNIRLWALQ LIFVTCPSLL VILHVAYREE RERRHRQKHG DQCAKLYDNA GKKHGGLWWT YLFSLIFKLI IEFLFLYLLH TLWHGFNMPR LVQCANVAPC PNIVDCYIAR PTEKKIFTYF MVGASAVCIV LTICELCYLI CHRVLRGLHK DKPRGGCSPS SSASRASTCR CHHKLVEAGE VDPDPGNNKL QASAPNLTPI
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