Epididymal secretory glutathione peroxidase (GPX5)

About Epididymal secretory glutathione peroxidase

Epididymal secretory glutathione peroxidase (GPX5) is a protein from Homo sapiens identified by UniProt accession O75715, 221 residues long. MolForge cross-references it against 0 known binders and 100 disease associations.

Target properties

Protein name	Epididymal secretory glutathione peroxidase
UniProt accession	O75715
Gene	GPX5
Organism	Homo sapiens
Length	221 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (100)

Diseases linked to this target (Open Targets).

breast adenocarcinoma · score 0.18
azoospermia · score 0.10
malignant epithelial tumor of ovary · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.08
mean corpuscular volume · score 0.07
calcium measurement · score 0.07
HbA1c measurement · score 0.07
partial chromosome Y deletion · score 0.07
spermatogenic failure 20 · score 0.06
sitting height measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75715-F1	alphafold	PREDICTED	90.80	—

Amino-acid sequence (221 residues)

MTTQLRVVHL LPLLLACFVQ TSPKQEKMKM DCHKDEKGTI YDYEAIALNK NEYVSFKQYV GKHILFVNVA TYCGLTAQYP ELNALQEELK PYGLVVLGFP CNQFGKQEPG DNKEILPGLK YVRPGGGFVP SFQLFEKGDV NGEKEQKVFS FLKHSCPHPS EILGTFKSIS WDPVKVHDIR WNFEKFLVGP DGIPVMRWSH RATVSSVKTD ILAYLKQFKT K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards