About Cartilage-associated protein
Cartilage-associated protein (CRTAP) is a protein
from Homo sapiens identified by UniProt accession
O75718, 401 residues long.
MolForge cross-references it against 0 known binders and
198 disease associations.
Target properties
| Protein name | Cartilage-associated protein |
|---|
| UniProt accession | O75718 |
|---|
| Gene | CRTAP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 401 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (198)
Diseases linked to this target (Open Targets).
- osteogenesis imperfecta · score 0.58
- osteogenesis imperfecta type 4 · score 0.38
- osteogenesis imperfecta type 3 · score 0.38
- Cole-Carpenter syndrome · score 0.37
- osteogenesis imperfecta type 2 · score 0.37
- Skeletal dysplasia · score 0.37
- breast adenocarcinoma · score 0.23
- genetic disorder · score 0.19
- unipolar depression · score 0.17
- Abnormality of refraction · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75718-F1 | alphafold | PREDICTED | 88.31 | — |
Amino-acid sequence (401 residues)
MEPGRRGAAA LLALLCVACA LRAGRAQYER YSFRSFPRDE LMPLESAYRH ALDKYSGEHW AESVGYLEIS LRLHRLLRDS EAFCHRNCSA APQPEPAAGL ASYPELRLFG GLLRRAHCLK RCKQGLPAFR QSQPSREVLA DFQRREPYKF LQFAYFKANN LPKAIAAAHT FLLKHPDDEM MKRNMAYYKS LPGAEDYIKD LETKSYESLF IRAVRAYNGE NWRTSITDME LALPDFFKAF YECLAACEGS REIKDFKDFY LSIADHYVEV LECKIQCEEN LTPVIGGYPV EKFVATMYHY LQFAYYKLND LKNAAPCAVS YLLFDQNDKV MQQNLVYYQY HRDTWGLSDE HFQPRPEAVQ FFNVTTLQKE LYDFAKENIM DDDEGEVVEY VDDLLELEET S
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