About Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma
Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma (PIK3C2G) is a protein
from Homo sapiens identified by UniProt accession
O75747, 1486 residues long.
MolForge cross-references it against 0 known binders and
134 disease associations.
Target properties
| Protein name | Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma |
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| UniProt accession | O75747 |
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| Gene | PIK3C2G |
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| Organism | Homo sapiens |
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| Length | 1486 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (134)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.32
- glioblastoma multiforme · score 0.26
- Tracheoesophageal fistula · score 0.26
- breast adenocarcinoma · score 0.25
- glucose measurement · score 0.24
- head and neck squamous cell carcinoma · score 0.19
- white matter microstructure measurement · score 0.19
- lung adenocarcinoma · score 0.19
- cutaneous melanoma · score 0.18
- total blood protein measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75747-F1 | alphafold | PREDICTED | 73.60 | — |
Amino-acid sequence (1486 residues)
MAYSWQTDPN PNESHEKQYE HQEFLFVNQP HSSSQVSLGF DQIVDEISGK IPHYESEIDE NTFFVPTAPK WDSTGHSLNE AHQISLNEFT SKSRELSWHQ VSKAPAIGFS PSVLPKPQNT NKECSWGSPI GKHHGADDSR FSILAPSFTS LDKINLEKEL ENENHNYHIG FESSIPPTNS SFSSDFMPKE ENKRSGHVNI VEPSLMLLKG SLQPGMWEST WQKNIESIGC SIQLVEVPQS SNTSLASFCN KVKKIRERYH AADVNFNSGK IWSTTTAFPY QLFSKTKFNI HIFIDNSTQP LHFMPCANYL VKDLIAEILH FCTNDQLLPK DHILSVCGSE EFLQNDHCLG SHKMFQKDKS VIQLHLQKSR EAPGKLSRKH EEDHSQFYLN QLLEFMHIWK VSRQCLLTLI RKYDFHLKYL LKTQENVYNI IEEVKKICSV LGCVETKQIT DAVNELSLIL QRKGENFYQS SETSAKGLIE KVTTELSTSI YQLINVYCNS FYADFQPVNV PRCTSYLNPG LPSHLSFTVY AAHNIPETWV HSYKAFSFTC WLTYAGKKLC QVRNYRNIPD KKLFFFLVNW NETINFPLEI KSLPRESMLT VKLFGIACAT NNANLLAWTC LPLFPKEKSI LGSMLFSMTL QSEPPVEMIT PGVWDVSQPS PVTLQIDFPA TGWEYMKPDS EENRSNLEEP LKECIKHIAR LSQKQTPLLL SEEKKRYLWF YRFYCNNENC SLPLVLGSAP GWDERTVSEM HTILRRWTFS QPLEALGLLT SSFPDQEIRK VAVQQLDNLL NDELLEYLPQ LVQAVKFEWN LESPLVQLLL HRSLQSIQVA HRLYWLLKNA ENEAYFKSWY QKLLAALQFC AGKALNDEFS KEQKLIKILG DIGERVKSAS DHQRQEVLKK EIGRLEEFFQ DVNTCHLPLN PALCIKGIDH DACSYFTSNA LPLKITFINA NPMGKNISII FKAGDDLRQD MLVLQLIQVM DNIWLQEGLD MQMIIYRCLS TGKDQGLVQM VPDAVTLAKI HRHSGLIGPL KENTIKKWFS QHNHLKADYE KALRNFFYSC AGWCVVTFIL GVCDRHNDNI MLTKSGHMFH IDFGKFLGHA QTFGGIKRDR APFIFTSEME YFITEGGKNP QHFQDFVELC CRAYNIIRKH SQLLLNLLEM MLYAGLPELS GIQDLKYVYN NLRPQDTDLE ATSHFTKKIK ESLECFPVKL NNLIHTLAQM SAISPAKSTS QTFPQESCLL STTRSIERAT ILGFSKKSSN LYLIQVTHSN NETSLTEKSF EQFSKLHSQL QKQFASLTLP EFPHWWHLPF TNSDHRRFRD LNHYMEQILN VSHEVTNSDC VLSFFLSEAV QQTVEESSPV YLGEKFPDKK PKVQLVISYE DVKLTILVKH MKNIHLPDGS APSAHVEFYL LPYPSEVRRR KTKSVPKCTD PTYNEIVVYD EVTELQGHVL MLIVKSKTVF VGAINIRLCS VPLDKEKWYP LGNSII
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