Transcription elongation factor A protein 3 (TCEA3)

About Transcription elongation factor A protein 3

Transcription elongation factor A protein 3 (TCEA3) is a protein from Homo sapiens identified by UniProt accession O75764, 348 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.

Target properties

Protein name	Transcription elongation factor A protein 3
UniProt accession	O75764
Gene	TCEA3
Organism	Homo sapiens
Length	348 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (73)

Diseases linked to this target (Open Targets).

electrocardiography · score 0.37
calcium measurement · score 0.32
sex hormone-binding globulin measurement · score 0.32
apolipoprotein A 1 measurement · score 0.31
high density lipoprotein cholesterol measurement · score 0.31
BMI-adjusted waist-hip ratio · score 0.29
waist-hip ratio · score 0.29
QT interval · score 0.27
total blood protein measurement · score 0.23
low density lipoprotein cholesterol measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75764-F1	alphafold	PREDICTED	74.12	—

Amino-acid sequence (348 residues)

MGQEEELLRI AKKLEKMVAR KNTEGALDLL KKLHSCQMSI QLLQTTRIGV AVNGVRKHCS DKEVVSLAKV LIKNWKRLLD SPGPPKGEKG EEREKAKKKE KGLECSDWKP EAGLSPPRKK REDPKTRRDS VDSKSSASSS PKRPSVERSN SSKSKAESPK TPSSPLTPTF ASSMCLLAPC YLTGDSVRDK CVEMLSAALK ADDDYKDYGV NCDKMASEIE DHIYQELKST DMKYRNRVRS RISNLKDPRN PGLRRNVLSG AISAGLIAKM TAEEMASDEL RELRNAMTQE AIREHQMAKT GGTTTDLFQC SKCKKKNCTY NQVQTRSADE PMTTFVLCNE CGNRWKFC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards