DNA repair protein RAD51 homolog 4 (RAD51D)

About DNA repair protein RAD51 homolog 4

DNA repair protein RAD51 homolog 4 (RAD51D) is a protein from Homo sapiens identified by UniProt accession O75771, 328 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.

Target properties

Protein name	DNA repair protein RAD51 homolog 4
UniProt accession	O75771
Gene	RAD51D
Organism	Homo sapiens
Length	328 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (80)

Diseases linked to this target (Open Targets).

Hereditary breast and ovarian cancer syndrome · score 0.74
ovarian cancer · score 0.66
hereditary neoplastic syndrome · score 0.58
Inherited cancer-predisposing syndrome · score 0.57
ovarian neoplasm · score 0.57
hereditary breast ovarian cancer syndrome · score 0.56
cancer · score 0.53
gastric cancer · score 0.52
breast cancer · score 0.51
ovarian carcinoma · score 0.45

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75771-F1	alphafold	PREDICTED	88.06	—

Amino-acid sequence (328 residues)

MGVLRVGLCP GLTEEMIQLL RSHRIKTVVD LVSADLEEVA QKCGLSYKAL VALRRVLLAQ FSAFPVNGAD LYEELKTSTA ILSTGIGSLD KLLDAGLYTG EVTEIVGGPG SGKTQVCLCM AANVAHGLQQ NVLYVDSNGG LTASRLLQLL QAKTQDEEEQ AEALRRIQVV HAFDIFQMLD VLQELRGTVA QQVTGSSGTV KVVVVDSVTA VVSPLLGGQQ REGLALMMQL ARELKTLARD LGMAVVVTNH ITRDRDSGRL KPALGRSWSF VPSTRILLDT IEGAGASGGR RMACLAKSSR QPTGFQEMVD IGTWGTSEQS ATLQGDQT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards