Paralemmin-1 (PALM)

About Paralemmin-1

Paralemmin-1 (PALM) is a protein from Homo sapiens identified by UniProt accession O75781, 387 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	Paralemmin-1
UniProt accession	O75781
Gene	PALM
Organism	Homo sapiens
Length	387 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

cognitive function measurement · score 0.26
worry measurement · score 0.23
mathematical ability · score 0.20
mean platelet volume · score 0.14
MODY · score 0.08
diabetes mellitus, transient neonatal, 2 · score 0.05
platelet component distribution width · score 0.05
hyperlipoproteinemia type V · score 0.05
Hyperlipoproteinemia type 5 · score 0.05
neoplasm · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75781-F1	alphafold	PREDICTED	69.03	—

Amino-acid sequence (387 residues)

MEVLAAETTS QQERLQAIAE KRKRQAEIEN KRRQLEDERR QLQHLKSKAL RERWLLEGTP SSASEGDEDL RRQMQDDEQK TRLLEDSVSR LEKEIEVLER GDSAPATAKE NAAAPSPVRA PAPSPAKEER KTEVVMNSQQ TPVGTPKDKR VSNTPLRTVD GSPMMKAAMY SVEITVEKDK VTGETRVLSS TTLLPRQPLP LGIKVYEDET KVVHAVDGTA ENGIHPLSSS EVDELIHKAD EVTLSEAGST AGAAETRGAV EGAARTTPSR REITGVQAQP GEATSGPPGI QPGQEPPVTM IFMGYQNVED EAETKKVLGL QDTITAELVV IEDAAEPKEP APPNGSAAEP PTEAASREEN QAGPEATTSD PQDLDMKKHR CKCCSIM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards