Rhomboid-related protein 1 (RHBDL1)

About Rhomboid-related protein 1

Rhomboid-related protein 1 (RHBDL1) is a protein from Homo sapiens identified by UniProt accession O75783, 438 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	Rhomboid-related protein 1
UniProt accession	O75783
Gene	RHBDL1
Organism	Homo sapiens
Length	438 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

platelet count · score 0.06
isolated asymptomatic elevation of creatine phosphokinase · score 0.05
pentosuria · score 0.05
Crigler-Najjar syndrome type 2 · score 0.04
self reported educational attainment · score 0.04
transient familial neonatal hyperbilirubinemia · score 0.03
gluthathione peroxidase deficiency · score 0.03
hypercholanemia, familial, 2 · score 0.03
platelet crit · score 0.03
Rotor syndrome · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75783-F1	alphafold	PREDICTED	72.57	—

Amino-acid sequence (438 residues)

MGRVEDGGTT EELEDWDPGT SALPAPGIKQ GPREQTGTGP LSQKCWEPEP DAPSQPGPAL WSRGRARTQA LAGGSSLQQL DPENTGFIGA DTFTGLVHSH ELPLDPAKLD MLVALAQSNE QGQVCYQELV DLISSKRSSS FKRAIANGQR ALPRDGPLDE PGLGVYKRFV RYVAYEILPC EVDRRWYFYR HRSCPPPVFM ASVTLAQIIV FLCYGARLNK WVLQTYHPEY MKSPLVYHPG HRARAWRFLT YMFMHVGLEQ LGFNALLQLM IGVPLEMVHG LLRISLLYLA GVLAGSLTVS ITDMRAPVVG GSGGVYALCS AHLANVVMNW AGMRCPYKLL RMVLALVCMS SEVGRAVWLR FSPPLPASGP QPSFMAHLAG AVVGVSMGLT ILRSYEERLR DQCGWWVVLL AYGTFLLFAV FWNVFAYDLL GAHIPPPP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards