Renin receptor (ATP6AP2)

About Renin receptor

Renin receptor (ATP6AP2) is a protein from Homo sapiens identified by UniProt accession O75787, 350 residues long. MolForge cross-references it against 0 known binders and 243 disease associations.

Target properties

Protein name	Renin receptor
UniProt accession	O75787
Gene	ATP6AP2
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (243)

Diseases linked to this target (Open Targets).

syndromic X-linked intellectual disability Hedera type · score 0.67
neurodegenerative disease · score 0.54
congenital disorder of glycosylation type II · score 0.53
X-linked parkinsonism-spasticity syndrome · score 0.51
X-linked intellectual disability, Hedera type · score 0.50
ATP6AP2-related disorder · score 0.41
X-linked intellectual disability - epilepsy · score 0.37
endometrial cancer · score 0.18
genetic disorder · score 0.18
cutaneous melanoma · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75787-F1	alphafold	PREDICTED	79.16	—

Amino-acid sequence (350 residues)

MAVFVVLLAL VAGVLGNEFS ILKSPGSVVF RNGNWPIPGE RIPDVAALSM GFSVKEDLSW PGLAVGNLFH RPRATVMVMV KGVNKLALPP GSVISYPLEN AVPFSLDSVA NSIHSLFSEE TPVVLQLAPS EERVYMVGKA NSVFEDLSVT LRQLRNRLFQ ENSVLSSLPL NSLSRNNEVD LLFLSELQVL HDISSLLSRH KHLAKDHSPD LYSLELAGLD EIGKRYGEDS EQFRDASKIL VDALQKFADD MYSLYGGNAV VELVTVKSFD TSLIRKTRTI LEAKQAKNPA SPYNLAYKYN FEYSVVFNMV LWIMIALALA VIITSYNIWN MDPGYDSIIY RMTNQKIRMD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards