GRB2-related adapter protein 2 (GRAP2)

About GRB2-related adapter protein 2

GRB2-related adapter protein 2 (GRAP2) is a protein from Homo sapiens identified by UniProt accession O75791, 330 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.

Target properties

Protein name	GRB2-related adapter protein 2
UniProt accession	O75791
Gene	GRAP2
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (117)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.44
eosinophil count · score 0.29
glioblastoma multiforme · score 0.26
breast adenocarcinoma · score 0.25
eosinophil percentage of leukocytes · score 0.23
multiple sclerosis · score 0.23
systemic lupus erythematosus · score 0.17
response to statin · score 0.14
head and neck squamous cell carcinoma · score 0.12
lung adenocarcinoma · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75791-F1	alphafold	PREDICTED	70.25	—

Amino-acid sequence (330 residues)

MEAVAKFDFT ASGEDELSFH TGDVLKILSN QEEWFKAELG SQEGYVPKNF IDIQFPKWFH EGLSRHQAEN LLMGKEVGFF IIRASQSSPG DFSISVRHED DVQHFKVMRD NKGNYFLWTE KFPSLNKLVD YYRTNSISRQ KQIFLRDRTR EDQGHRGNSL DRRSQGGPHL SGAVGEEIRP SMNRKLSDHP PTLPLQQHQH QPQPPQYAPA PQQLQQPPQQ RYLQHHHFHQ ERRGGSLDIN DGHCGTGLGS EMNAALMHRR HTDPVQLQAA GRVRWARALY DFEALEDDEL GFHSGEVVEV LDSSNPSWWT GRLHNKLGLF PANYVAPMTR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards