Ribonuclease H2 subunit A (RNASEH2A)

About Ribonuclease H2 subunit A

Ribonuclease H2 subunit A (RNASEH2A) is a protein from Homo sapiens identified by UniProt accession O75792, 299 residues long. MolForge cross-references it against 0 known binders and 153 disease associations.

Target properties

Protein name	Ribonuclease H2 subunit A
UniProt accession	O75792
Gene	RNASEH2A
Organism	Homo sapiens
Length	299 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (153)

Diseases linked to this target (Open Targets).

Aicardi-Goutières syndrome · score 0.83
Aicardi-Goutieres syndrome · score 0.62
genetic disorder · score 0.45
mathematical ability · score 0.22
cancer · score 0.09
hepatocellular carcinoma · score 0.08
beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.06
dehydrated hereditary stomatocytosis · score 0.05
hemoglobin D disease · score 0.05
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75792-F1	alphafold	PREDICTED	87.76	—

Amino-acid sequence (299 residues)

MDLSELERDN TGRCRLSSPV PAVCRKEPCV LGVDEAGRGP VLGPMVYAIC YCPLPRLADL EALKVADSKT LLESERERLF AKMEDTDFVG WALDVLSPNL ISTSMLGRVK YNLNSLSHDT ATGLIQYALD QGVNVTQVFV DTVGMPETYQ ARLQQSFPGI EVTVKAKADA LYPVVSAASI CAKVARDQAV KKWQFVEKLQ DLDTDYGSGY PNDPKTKAWL KEHVEPVFGF PQFVRFSWRT AQTILEKEAE DVIWEDSASE NQEGLRKITS YFLNEGSQAR PRSSHRYFLE RGLESATSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards