About Protein phosphatase 1 regulatory subunit 15A
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) is a protein
from Homo sapiens identified by UniProt accession
O75807, 674 residues long.
MolForge cross-references it against 0 known binders and
344 disease associations.
Target properties
| Protein name | Protein phosphatase 1 regulatory subunit 15A |
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| UniProt accession | O75807 |
|---|
| Gene | PPP1R15A |
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| Organism | Homo sapiens |
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| Length | 674 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (344)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- Red cell distribution width · score 0.40
- reticulocyte count · score 0.40
- mean corpuscular volume · score 0.35
- mean corpuscular hemoglobin concentration · score 0.35
- mean corpuscular hemoglobin · score 0.35
- Immature Reticulocyte Fraction Measurement · score 0.27
- serum gamma-glutamyl transferase measurement · score 0.23
- reticulocyte measurement · score 0.20
- grip strength measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75807-F1 | alphafold | PREDICTED | 49.46 | — |
Amino-acid sequence (674 residues)
MAPGQAPHQA TPWRDAHPFF LLSPVMGLLS RAWSRLRGLG PLEPWLVEAV KGAALVEAGL EGEARTPLAI PHTPWGRRPE EEAEDSGGPG EDRETLGLKT SSSLPEAWGL LDDDDGMYGE REATSVPRGQ GSQFADGQRA PLSPSLLIRT LQGSDKNPGE EKAEEEGVAE EEGVNKFSYP PSHRECCPAV EEEDDEEAVK KEAHRTSTSA LSPGSKPSTW VSCPGEEENQ ATEDKRTERS KGARKTSVSP RSSGSDPRSW EYRSGEASEE KEEKAHKETG KGEAAPGPQS SAPAQRPQLK SWWCQPSDEE EGEVKALGAA EKDGEAECPP CIPPPSAFLK AWVYWPGEDT EEEEDEEEDE DSDSGSDEEE GEAEASSSTP ATGVFLKSWV YQPGEDTEEE EDEDSDTGSA EDEREAETSA STPPASAFLK AWVYRPGEDT EEEEDEDVDS EDKEDDSEAA LGEAESDPHP SHPDQRAHFR GWGYRPGKET EEEEAAEDWG EAEPCPFRVA IYVPGEKPPP PWAPPRLPLR LQRRLKRPET PTHDPDPETP LKARKVRFSE KVTVHFLAVW AGPAQAARQG PWEQLARDRS RFARRITQAQ EELSPCLTPA ARARAWARLR NPPLAPIPAL TQTLPSSSVP SSPVQTTPLS QAVATPSRSS AAAAAALDLS GRRG
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