About Carbonyl reductase [NADPH] 3
Carbonyl reductase [NADPH] 3 (CBR3) is a protein
from Homo sapiens identified by UniProt accession
O75828, 277 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Carbonyl reductase [NADPH] 3 |
|---|
| UniProt accession | O75828 |
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| Gene | CBR3 |
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| Organism | Homo sapiens |
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| Length | 277 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (63)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.41
- neurodegenerative disease · score 0.22
- mean corpuscular volume · score 0.10
- C-reactive protein measurement · score 0.10
- PHF-tau measurement · score 0.09
- red blood cell density measurement · score 0.08
- non-small cell lung carcinoma · score 0.08
- hematocrit · score 0.08
- hemoglobin measurement · score 0.08
- IGF-1 measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75828-F1 | alphafold | PREDICTED | 96.56 | — |
Amino-acid sequence (277 residues)
MSSCSRVALV TGANRGIGLA IARELCRQFS GDVVLTARDV ARGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLNVLVNN AAVAFKSDDP MPFDIKAEMT LKTNFFATRN MCNELLPIMK PHGRVVNISS LQCLRAFENC SEDLQERFHS ETLTEGDLVD LMKKFVEDTK NEVHEREGWP NSPYGVSKLG VTVLSRILAR RLDEKRKADR ILVNACCPGP VKTDMDGKDS IRTVEEGAET PVYLALLPPD ATEPQGQLVH DKVVQNW
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