Serpin I2 (SERPINI2)

About Serpin I2

Serpin I2 (SERPINI2) is a protein from Homo sapiens identified by UniProt accession O75830, 405 residues long. MolForge cross-references it against 0 known binders and 96 disease associations.

Target properties

Protein name	Serpin I2
UniProt accession	O75830
Gene	SERPINI2
Organism	Homo sapiens
Length	405 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (96)

Diseases linked to this target (Open Targets).

diet measurement · score 0.44
worry measurement · score 0.09
electrocardiography · score 0.09
DNA methylation · score 0.06
immunodeficiency 76 · score 0.05
protein measurement · score 0.04
T-B+ severe combined immunodeficiency due to JAK3 deficiency · score 0.04
immunodeficiency 19 · score 0.04
immunodeficiency 84 · score 0.04
severe combined immunodeficiency due to IKK2 deficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75830-F1	alphafold	PREDICTED	85.96	—

Amino-acid sequence (405 residues)

MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL GITLVLEMVQ LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK QEFTFNLANA LYLQEGFTVK EQYLHGNKEF FQSAIKLVDF QDAKACAEMI STWVERKTDG KIKDMFSGEE FGPLTRLVLV NAIYFKGDWK QKFRKEDTQL INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS YKGDEFSLII ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST GIHIPVIMSL AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR DLDSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards