About 26S proteasome non-ATPase regulatory subunit 10
26S proteasome non-ATPase regulatory subunit 10 (PSMD10) is a protein
from Homo sapiens identified by UniProt accession
O75832, 226 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | 26S proteasome non-ATPase regulatory subunit 10 |
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| UniProt accession | O75832 |
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| Gene | PSMD10 |
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| Organism | Homo sapiens |
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| Length | 226 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (133)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.46
- ovarian cancer · score 0.29
- endometrial cancer · score 0.29
- lung adenocarcinoma · score 0.29
- head and neck squamous cell carcinoma · score 0.28
- gastric adenocarcinoma · score 0.27
- small cell lung carcinoma · score 0.22
- hepatocellular carcinoma · score 0.11
- non-small cell lung carcinoma · score 0.10
- neoplasm · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75832-F1 | alphafold | PREDICTED | 95.38 | — |
Amino-acid sequence (226 residues)
MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG
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