About Calcium and integrin-binding family member 2
Calcium and integrin-binding family member 2 (CIB2) is a protein
from Homo sapiens identified by UniProt accession
O75838, 187 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Calcium and integrin-binding family member 2 |
|---|
| UniProt accession | O75838 |
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| Gene | CIB2 |
|---|
| Organism | Homo sapiens |
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| Length | 187 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (65)
Diseases linked to this target (Open Targets).
- deafness · score 0.64
- Usher syndrome · score 0.63
- Usher syndrome type 1 · score 0.63
- hearing loss, autosomal recessive · score 0.61
- neurodegenerative disease · score 0.43
- nonsyndromic genetic hearing loss · score 0.37
- hearing loss · score 0.37
- Rare genetic deafness · score 0.34
- Hearing impairment · score 0.34
- diet measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75838-F1 | alphafold | PREDICTED | 88.61 | — |
Amino-acid sequence (187 residues)
MGNKQTIFTE EQLDNYQDCT FFNKKDILKL HSRFYELAPN LVPMDYRKSP IVHVPMSLII QMPELRENPF KERIVAAFSE DGEGNLTFND FVDMFSVLCE SAPRELKANY AFKIYDFNTD NFICKEDLEL TLARLTKSEL DEEEVVLVCD KVIEEADLDG DGKLGFADFE DMIAKAPDFL STFHIRI
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