About Krueppel-like factor 7
Krueppel-like factor 7 (KLF7) is a protein
from Homo sapiens identified by UniProt accession
O75840, 302 residues long.
MolForge cross-references it against 0 known binders and
139 disease associations.
Target properties
| Protein name | Krueppel-like factor 7 |
|---|
| UniProt accession | O75840 |
|---|
| Gene | KLF7 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 302 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (139)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- hemoglobin measurement · score 0.48
- erythrocyte count · score 0.48
- hematocrit · score 0.46
- body mass index · score 0.46
- lean body mass · score 0.46
- Intellectual disability · score 0.44
- neuroticism measurement · score 0.44
- genetic disorder · score 0.41
- eosinophil count · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75840-F1 | alphafold | PREDICTED | 53.38 | — |
Amino-acid sequence (302 residues)
MDVLASYSIF QELQLVHDTG YFSALPSLEE TWQQTCLELE RYLQTEPRRI SETFGEDLDC FLHASPPPCI EESFRRLDPL LLPVEAAICE KSSAVDILLS RDKLLSETCL SLQPASSSLD SYTAVNQAQL NAVTSLTPPS SPELSRHLVK TSQTLSAVDG TVTLKLVAKK AALSSVKVGG VATAAAAVTA AGAVKSGQSD SDQGGLGAEA CPENKKRVHR CQFNGCRKVY TKSSHLKAHQ RTHTGEKPYK CSWEGCEWRF ARSDELTRHY RKHTGAKPFK CNHCDRCFSR SDHLALHMKR HI
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