CAAX prenyl protease 1 homolog (ZMPSTE24)

About CAAX prenyl protease 1 homolog

CAAX prenyl protease 1 homolog (ZMPSTE24) is a protein from Homo sapiens identified by UniProt accession O75844, 475 residues long. MolForge cross-references it against 0 known binders and 298 disease associations.

Target properties

Protein name	CAAX prenyl protease 1 homolog
UniProt accession	O75844
Gene	ZMPSTE24
Organism	Homo sapiens
Length	475 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (298)

Diseases linked to this target (Open Targets).

mandibuloacral dysplasia with type B lipodystrophy · score 0.80
Lethal restrictive dermopathy · score 0.74
restrictive dermopathy 1 · score 0.60
Hutchinson-Gilford progeria syndrome · score 0.38
restrictive dermopathy · score 0.37
mandibuloacral dysplasia · score 0.19
genetic disorder · score 0.19
infect · score 0.08
infection · score 0.08
Alopecia universalis · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75844-F1	alphafold	PREDICTED	89.46	—

Amino-acid sequence (475 residues)

MGMWASLDAL WEMPAEKRIF GAVLLFSWTV YLWETFLAQR QRRIYKTTTH VPPELGQIMD SETFEKSRLY QLDKSTFSFW SGLYSETEGT LILLFGGIPY LWRLSGRFCG YAGFGPEYEI TQSLVFLLLA TLFSALTGLP WSLYNTFVIE EKHGFNQQTL GFFMKDAIKK FVVTQCILLP VSSLLLYIIK IGGDYFFIYA WLFTLVVSLV LVTIYADYIA PLFDKFTPLP EGKLKEEIEV MAKSIDFPLT KVYVVEGSKR SSHSNAYFYG FFKNKRIVLF DTLLEEYSVL NKDIQEDSGM EPRNEEEGNS EEIKAKVKNK KQGCKNEEVL AVLGHELGHW KLGHTVKNII ISQMNSFLCF FLFAVLIGRK ELFAAFGFYD SQPTLIGLLI IFQFIFSPYN EVLSFCLTVL SRRFEFQADA FAKKLGKAKD LYSALIKLNK DNLGFPVSDW LFSMWHYSHP PLLERLQALK TMKQH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards