About Lathosterol oxidase
Lathosterol oxidase (SC5D) is a protein
from Homo sapiens identified by UniProt accession
O75845, 299 residues long.
MolForge cross-references it against 0 known binders and
220 disease associations.
Target properties
| Protein name | Lathosterol oxidase |
|---|
| UniProt accession | O75845 |
|---|
| Gene | SC5D |
|---|
| Organism | Homo sapiens |
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| Length | 299 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (220)
Diseases linked to this target (Open Targets).
- lathosterolosis · score 0.78
- Intellectual disability · score 0.46
- Cataract · score 0.46
- neurodegenerative disease · score 0.22
- genetic disorder · score 0.18
- metabolite measurement · score 0.08
- Syndactyly type 2 · score 0.07
- syndactyly type 4 · score 0.07
- syndactyly type 1 · score 0.06
- syndactyly type 3 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75845-F1 | alphafold | PREDICTED | 91.70 | — |
Amino-acid sequence (299 residues)
MDLVLRVADY YFFTPYVYPA TWPEDDIFRQ AISLLIVTNV GAYILYFFCA TLSYYFVFDH ALMKHPQFLK NQVRREIKFT VQALPWISIL TVALFLLEIR GYSKLHDDLG EFPYGLFELV VSIISFLFFT DMFIYWIHRG LHHRLVYKRL HKPHHIWKIP TPFASHAFHP IDGFLQSLPY HIYPFIFPLH KVVYLSLYIL VNIWTISIHD GDFRVPQILQ PFINGSAHHT DHHMFFDYNY GQYFTLWDRI GGSFKNPSSF EGKGPLSYVK EMTEGKRSSH SGNGCKNEKL FNGEFTKTE
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