About Protein phosphatase 1 regulatory subunit 37
Protein phosphatase 1 regulatory subunit 37 (PPP1R37) is a protein
from Homo sapiens identified by UniProt accession
O75864, 691 residues long.
MolForge cross-references it against 0 known binders and
8 disease associations.
Target properties
| Protein name | Protein phosphatase 1 regulatory subunit 37 |
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| UniProt accession | O75864 |
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| Gene | PPP1R37 |
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| Organism | Homo sapiens |
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| Length | 691 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (8)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- low density lipoprotein cholesterol measurement · score 0.22
- adolescent idiopathic scoliosis · score 0.11
- family history of Alzheimer’s disease · score 0.10
- mean corpuscular volume · score 0.08
- beta-amyloid 1-42 measurement · score 0.05
- alkaline phosphatase measurement · score 0.04
- hepatocellular carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75864-F1 | alphafold | PREDICTED | 73.22 | — |
Amino-acid sequence (691 residues)
MEIAPQEAPP VPGADGDIEE APAEAGSPSP ASPPADGRLK AAAKRVTFPS DEDIVSGAVE PKDPWRHAQN VTVDEVIGAY KQACQKLNCR QIPKLLRQLQ EFTDLGHRLD CLDLKGEKLD YKTCEALEEV FKRLQFKVVD LEQTNLDEDG ASALFDMIEY YESATHLNIS FNKHIGTRGW QAAAHMMRKT SCLQYLDARN TPLLDHSAPF VARALRIRSS LAVLHLENAS LSGRPLMLLA TALKMNMNLR ELYLADNKLN GLQDSAQLGN LLKFNCSLQI LDLRNNHVLD SGLAYICEGL KEQRKGLVTL VLWNNQLTHT GMAFLGMTLP HTQSLETLNL GHNPIGNEGV RHLKNGLISN RSVLRLGLAS TKLTCEGAVA VAEFIAESPR LLRLDLRENE IKTGGLMALS LALKVNHSLL RLDLDREPKK EAVKSFIETQ KALLAEIQNG CKRNLVLARE REEKEQPPQL SASMPETTAT EPQPDDEPAA GVQNGAPSPA PSPDSDSDSD SDGEEEEEEE GERDETPCPA LVPPTDSLGP GDRSPPGSPS TPTEQRISVS SPGRGHKVFV VTRVESPPER AEPPASPTPP SPPPPPSPPA SPSLPPAGAI DTRDTGSSEP QPPPEPPRSG PPLPNGLKPE FALALPPEPP PGPEVKGGSC GLEHELSCSK NEKELEELLL EASQESGQET L
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