Cell adhesion molecule CEACAM4 (CEACAM4)

About Cell adhesion molecule CEACAM4

Cell adhesion molecule CEACAM4 (CEACAM4) is a protein from Homo sapiens identified by UniProt accession O75871, 244 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.

Target properties

Protein name	Cell adhesion molecule CEACAM4
UniProt accession	O75871
Gene	CEACAM4
Organism	Homo sapiens
Length	244 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (37)

Diseases linked to this target (Open Targets).

MODY · score 0.07
hyperproinsulinemia · score 0.07
hyperinsulinism due to INSR deficiency · score 0.07
hyperinsulinism due to glucokinase deficiency · score 0.06
neoplasm · score 0.06
exercise-induced hyperinsulinism · score 0.05
nonpapillary renal cell carcinoma · score 0.05
cholesterol-ester transfer protein deficiency · score 0.04
hypertriglyceridemia 2 · score 0.04
glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75871-F1	alphafold	PREDICTED	77.27	—

Amino-acid sequence (244 residues)

MGPPSAAPRG GHRPWQGLLI TASLLTFWHP PTTVQFTIEA LPSSAAEGKD VLLLACNISE TIQAYYWHKG KTAEGSPLIA GYITDIQANI PGAAYSGRET VYPNGSLLFQ NITLEDAGSY TLRTINASYD SDQATGQLHV HQNNVPGLPV GAVAGIVTGV LVGVALVAAL VCFLLLSRTG RASIQRDLRE QPPPASTPGH GPSHRSTFSA PLPSPRTATP IYEELLYSDA NIYCQIDHKA DVVS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards