About Isocitrate dehydrogenase [NADP] cytoplasmic
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) is a protein
from Homo sapiens identified by UniProt accession
O75874, 414 residues long.
MolForge cross-references it against 0 known binders and
599 disease associations.
Target properties
| Protein name | Isocitrate dehydrogenase [NADP] cytoplasmic |
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| UniProt accession | O75874 |
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| Gene | IDH1 |
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| Organism | Homo sapiens |
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| Length | 414 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (599)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.75
- glioblastoma multiforme · score 0.64
- Enchondromatosis · score 0.62
- Maffucci syndrome · score 0.62
- cholangiocarcinoma · score 0.61
- metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria · score 0.55
- melanoma · score 0.54
- low grade glioma · score 0.52
- prostate adenocarcinoma · score 0.51
- Ollier disease · score 0.51
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75874-F1 | alphafold | PREDICTED | 95.85 | — |
Amino-acid sequence (414 residues)
MSKKISGGSV VEMQGDEMTR IIWELIKEKL IFPYVELDLH SYDLGIENRD ATNDQVTKDA AEAIKKHNVG VKCATITPDE KRVEEFKLKQ MWKSPNGTIR NILGGTVFRE AIICKNIPRL VSGWVKPIII GRHAYGDQYR ATDFVVPGPG KVEITYTPSD GTQKVTYLVH NFEEGGGVAM GMYNQDKSIE DFAHSSFQMA LSKGWPLYLS TKNTILKKYD GRFKDIFQEI YDKQYKSQFE AQKIWYEHRL IDDMVAQAMK SEGGFIWACK NYDGDVQSDS VAQGYGSLGM MTSVLVCPDG KTVEAEAAHG TVTRHYRMYQ KGQETSTNPI ASIFAWTRGL AHRAKLDNNK ELAFFANALE EVSIETIEAG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK LGENLKIKLA QAKL
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