About Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (GATB) is a protein
from Homo sapiens identified by UniProt accession
O75879, 557 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial |
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| UniProt accession | O75879 |
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| Gene | GATB |
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| Organism | Homo sapiens |
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| Length | 557 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (40)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation deficiency 41 · score 0.53
- mathematical ability · score 0.31
- cognitive function measurement · score 0.26
- intelligence · score 0.26
- self reported educational attainment · score 0.26
- smoking status measurement · score 0.25
- reaction time measurement · score 0.20
- verbal-numerical reasoning measurement · score 0.20
- BMI-adjusted hip circumference · score 0.20
- body mass index · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75879-F1 | alphafold | PREDICTED | 85.40 | — |
Amino-acid sequence (557 residues)
MAAPMLRWGC RGRRWAFARV DGGSCHRRGA PTGSTSNQIR GESSVAQQPL HTAQKTRKGE HKWAAVVGLE IHAQISSNSK LFSGSQVRFS APPNSLVSFF DASLPGTLPV LNRRCVEAAV MTGLALNCHI NKKSLFDRKH YFYADLPAGY QITQQRLPIA VNGSLIYGVC AGKKQSQVIP KTVRIKQIQL EQDSGKSLHD NLRSQTLIDL NRAGVGLLEV VLEPDMSCGE EAATAVRELQ LILQALGTSQ ANMAEGQLRV DANISVHHPG EPLGVRTEVK NLNSIRFLAK AIDYEIQRQI NELENGGEIL NETRSFHHKL GCTMSMRDKE GKQDYRFMPE PNLPPLVLYD ATSLPAGADP QQVINIDQIR ETLPELPSVT REKLVQQYGM LLEHSFTLLN EVGLLEFFQN VIKETRAEPK KVTSWVLNTF LGYLKQQNLA VSESPVTPSA LAELLDLLDS RTISSSAAKQ VFEELWKREG KTPGQIVSEK QLELMQDQGA LEQLCHSVME AHPQVVMDVK NRNPRAINKL IGLVRKATQS RADPVMIKEI LEKKLSL
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