Cytochrome c oxidase assembly factor SCO1 (SCO1)

About Cytochrome c oxidase assembly factor SCO1

Cytochrome c oxidase assembly factor SCO1 (SCO1) is a protein from Homo sapiens identified by UniProt accession O75880, 301 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.

Target properties

Protein name	Cytochrome c oxidase assembly factor SCO1
UniProt accession	O75880
Gene	SCO1
Organism	Homo sapiens
Length	301 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (51)

Diseases linked to this target (Open Targets).

mitochondrial complex 4 deficiency, nuclear type 4 · score 0.73
neurodegenerative disease · score 0.48
cytochrome-c oxidase deficiency disease · score 0.46
mitochondrial complex IV deficiency, nuclear type 22 · score 0.42
leigh syndrome due to mitochondrial complex iv deficiency · score 0.42
mitochondrial disease · score 0.37
fatal infantile encephalocardiomyopathy · score 0.37
Leigh syndrome · score 0.19
genetic disorder · score 0.19
lung adenocarcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75880-F1	alphafold	PREDICTED	77.77	—

Amino-acid sequence (301 residues)

MAMLVLVPGR VMRPLGGQLW RFLPRGLEFW GPAEGTARVL LRQFCARQAE AWRASGRPGY CLGTRPLSTA RPPPPWSQKG PGDSTRPSKP GPVSWKSLAI TFAIGGALLA GMKHVKKEKA EKLEKERQRH IGKPLLGGPF SLTTHTGERK TDKDYLGQWL LIYFGFTHCP DVCPEELEKM IQVVDEIDSI TTLPDLTPLF ISIDPERDTK EAIANYVKEF SPKLVGLTGT REEVDQVARA YRVYYSPGPK DEDEDYIVDH TIIMYLIGPD GEFLDYFGQN KRKGEIAASI ATHMRPYRKK S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards