Cytochrome P450 7B1 (CYP7B1)

About Cytochrome P450 7B1

Cytochrome P450 7B1 (CYP7B1) is a protein from Homo sapiens identified by UniProt accession O75881, 506 residues long. MolForge cross-references it against 0 known binders and 211 disease associations.

Target properties

Protein name	Cytochrome P450 7B1
UniProt accession	O75881
Gene	CYP7B1
Organism	Homo sapiens
Length	506 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (211)

Diseases linked to this target (Open Targets).

Autosomal recessive spastic paraplegia type 5A · score 0.83
hereditary spastic paraplegia 5A · score 0.81
Congenital bile acid synthesis defect type 3 · score 0.67
hereditary spastic paraplegia · score 0.63
congenital bile acid synthesis defect 3 · score 0.59
Spastic paraplegia · score 0.56
genetic disorder · score 0.48
uterine benign neoplasm · score 0.37
neuroticism measurement · score 0.36
neurodegenerative disease · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75881-F1	alphafold	PREDICTED	91.55	—

Amino-acid sequence (506 residues)

MAGEVSAATG RFSLERLGLP GLALAAALLL LALCLLVRRT RRPGEPPLIK GWLPYLGVVL NLRKDPLRFM KTLQKQHGDT FTVLLGGKYI TFILDPFQYQ LVIKNHKQLS FRVFSNKLLE KAFSISQLQK NHDMNDELHL CYQFLQGKSL DILLESMMQN LKQVFEPQLL KTTSWDTAEL YPFCSSIIFE ITFTTIYGKV IVCDNNKFIS ELRDDFLKFD DKFAYLVSNI PIELLGNVKS IREKIIKCFS SEKLAKMQGW SEVFQSRQDV LEKYYVHEDL EIGAHHLGFL WASVANTIPT MFWAMYYLLR HPEAMAAVRD EIDRLLQSTG QKKGSGFPIH LTREQLDSLI CLESSIFEAL RLSSYSTTIR FVEEDLTLSS ETGDYCVRKG DLVAIFPPVL HGDPEIFEAP EEFRYDRFIE DGKKKTTFFK RGKKLKCYLM PFGTGTSKCP GRFFALMEIK QLLVILLTYF DLEIIDDKPI GLNYSRLLFG IQYPDSDVLF RYKVKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards