Tumor suppressor candidate 2 (TUSC2)

About Tumor suppressor candidate 2

Tumor suppressor candidate 2 (TUSC2) is a protein from Homo sapiens identified by UniProt accession O75896, 110 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.

Target properties

Protein name	Tumor suppressor candidate 2
UniProt accession	O75896
Gene	TUSC2
Organism	Homo sapiens
Length	110 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (85)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.26
neoplasm · score 0.08
malignant pleural mesothelioma · score 0.07
cognitive function measurement · score 0.07
self reported educational attainment · score 0.07
cancer · score 0.06
non-small cell lung carcinoma · score 0.06
Thymoma · score 0.05
autoimmune lymphoproliferative syndrome · score 0.05
autoinflammatory syndrome with immunodeficiency · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75896-F1	alphafold	PREDICTED	76.05	—

Amino-acid sequence (110 residues)

MGASGSKARG LWPFASAAGG GGSEAAGAEQ ALVRPRGRAV PPFVFTRRGS MFYDEDGDLA HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDHPRIH VDFPVILYEV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards