Ras association domain-containing protein 9 (RASSF9)

About Ras association domain-containing protein 9

Ras association domain-containing protein 9 (RASSF9) is a protein from Homo sapiens identified by UniProt accession O75901, 435 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.

Target properties

Protein name	Ras association domain-containing protein 9
UniProt accession	O75901
Gene	RASSF9
Organism	Homo sapiens
Length	435 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (88)

Diseases linked to this target (Open Targets).

hair colour measurement · score 0.29
diffuse plaque measurement · score 0.28
genetic disorder · score 0.12
Premature coronary artery atherosclerosis · score 0.12
smoking behavior · score 0.11
Alopecia-intellectual disability syndrome · score 0.10
Alopecia universalis · score 0.09
hypotrichosis simplex · score 0.08
uncombable hair syndrome · score 0.07
non-small cell lung carcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75901-F1	alphafold	PREDICTED	72.69	—

Amino-acid sequence (435 residues)

MAPFGRNLLK TRHKNRSPTK DMDSEEKEIV VWVCQEEKLV CGLTKRTTSA DVIQALLEEH EATFGEKRFL LGKPSDYCII EKWRGSERVL PPLTRILKLW KAWGDEQPNM QFVLVKADAF LPVPLWRTAE AKLVQNTEKL WELSPANYMK TLPPDKQKRI VRKTFRKLAK IKQDTVSHDR DNMETLVHLI ISQDHTIHQQ VKRMKELDLE IEKCEAKFHL DRVENDGENY VQDAYLMPSF SEVEQNLDLQ YEENQTLEDL SESDGIEQLE ERLKYYRILI DKLSAEIEKE VKSVCIDINE DAEGEAASEL ESSNLESVKC DLEKSMKAGL KIHSHLSGIQ KEIKYSDSLL QMKAKEYELL AKEFNSLHIS NKDGCQLKEN RAKESEVPSS NGEIPPFTQR VFSNYTNDTD SDTGISSNHS QDSETTVGDV VLLST

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards