About Diacylglycerol O-acyltransferase 1
Diacylglycerol O-acyltransferase 1 (DGAT1) is a protein
from Homo sapiens identified by UniProt accession
O75907, 488 residues long.
MolForge cross-references it against 0 known binders and
153 disease associations.
Target properties
| Protein name | Diacylglycerol O-acyltransferase 1 |
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| UniProt accession | O75907 |
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| Gene | DGAT1 |
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| Organism | Homo sapiens |
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| Length | 488 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (153)
Diseases linked to this target (Open Targets).
- Diarrhea · score 0.65
- congenital diarrhea 7 with exudative enteropathy · score 0.65
- Congenital chronic diarrhea with protein-losing enteropathy · score 0.46
- genetic disorder · score 0.41
- familial chylomicronemia syndrome · score 0.29
- glucose measurement · score 0.23
- HbA1c measurement · score 0.22
- type 2 diabetes mellitus · score 0.20
- glioblastoma multiforme · score 0.20
- vital capacity · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75907-F1 | alphafold | PREDICTED | 80.34 | — |
Amino-acid sequence (488 residues)
MGDRGSSRRR RTGSRPSSHG GGGPAAAEEE VRDAAAGPDV GAAGDAPAPA PNKDGDAGVG SGHWELRCHR LQDSLFSSDS GFSNYRGILN WCVVMLILSN ARLFLENLIK YGILVDPIQV VSLFLKDPYS WPAPCLVIAA NVFAVAAFQV EKRLAVGALT EQAGLLLHVA NLATILCFPA AVVLLVESIT PVGSLLALMA HTILFLKLFS YRDVNSWCRR ARAKAASAGK KASSAAAPHT VSYPDNLTYR DLYYFLFAPT LCYELNFPRS PRIRKRFLLR RILEMLFFTQ LQVGLIQQWM VPTIQNSMKP FKDMDYSRII ERLLKLAVPN HLIWLIFFYW LFHSCLNAVA ELMQFGDREF YRDWWNSESV TYFWQNWNIP VHKWCIRHFY KPMLRRGSSK WMARTGVFLA SAFFHEYLVS VPLRMFRLWA FTGMMAQIPL AWFVGRFFQG NYGNAAVWLS LIIGQPIAVL MYVHDYYVLN YEAPAAEA
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