About Cyclin-K
Cyclin-K (CCNK) is a protein
from Homo sapiens identified by UniProt accession
O75909, 580 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Cyclin-K |
|---|
| UniProt accession | O75909 |
|---|
| Gene | CCNK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 580 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (55)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.56
- intellectual developmental disorder with hypertelorism and distinctive facies · score 0.48
- neurodegenerative disease · score 0.43
- breast adenocarcinoma · score 0.23
- squamous cell lung carcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- endometrial cancer · score 0.18
- clear cell renal carcinoma · score 0.17
- gastric adenocarcinoma · score 0.17
- urinary bladder cancer · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75909-F1 | alphafold | PREDICTED | 65.12 | — |
Amino-acid sequence (580 residues)
MKENKENSSP SVTSANLDHT KPCWYWDKKD LAHTPSQLEG LDPATEARYR REGARFIFDV GTRLGLHYDT LATGIIYFHR FYMFHSFKQF PRYVTGACCL FLAGKVEETP KKCKDIIKTA RSLLNDVQFG QFGDDPKEEV MVLERILLQT IKFDLQVEHP YQFLLKYAKQ LKGDKNKIQK LVQMAWTFVN DSLCTTLSLQ WEPEIIAVAV MYLAGRLCKF EIQEWTSKPM YRRWWEQFVQ DVPVDVLEDI CHQILDLYSQ GKQQMPHHTP HQLQQPPSLQ PTPQVPQVQQ SQPSQSSEPS QPQQKDPQQP AQQQQPAQQP KKPSPQPSSP RQVKRAVVVS PKEENKAAEP PPPKIPKIET THPPLPPAHP PPDRKPPLAA ALGEAEPPGP VDATDLPKVQ IPPPAHPAPV HQPPPLPHRP PPPPPSSYMT GMSTTSSYMS GEGYQSLQSM MKTEGPSYGA LPPAYGPPAH LPYHPHVYPP NPPPPPVPPP PASFPPPAIP PPTPGYPPPP PTYNPNFPPP PPRLPPTHAV PPHPPPGLGL PPASYPPPAV PPGGQPPVPP PIPPPGMPPV GGLGRAAWMR
Explore Cyclin-K with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets