Short-chain dehydrogenase/reductase 3 (DHRS3)

About Short-chain dehydrogenase/reductase 3

Short-chain dehydrogenase/reductase 3 (DHRS3) is a protein from Homo sapiens identified by UniProt accession O75911, 302 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

Target properties

Protein name	Short-chain dehydrogenase/reductase 3
UniProt accession	O75911
Gene	DHRS3
Organism	Homo sapiens
Length	302 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

hemoglobin measurement · score 0.42
hematocrit · score 0.42
erythrocyte count · score 0.41
red blood cell density measurement · score 0.36
mean corpuscular hemoglobin concentration · score 0.29
cup-to-disc ratio measurement · score 0.27
sitting height measurement · score 0.23
optic cup area measurement · score 0.18
cutaneous melanoma · score 0.17
craniosynostosis · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75911-F1	alphafold	PREDICTED	94.19	—

Amino-acid sequence (302 residues)

MVWKRLGALV MFPLQMIYLV VKAAVGLVLP AKLRDLSREN VLITGGGRGI GRQLAREFAE RGARKIVLWG RTEKCLKETT EEIRQMGTEC HYFICDVGNR EEVYQTAKAV REKVGDITIL VNNAAVVHGK SLMDSDDDAL LKSQHINTLG QFWTTKAFLP RMLELQNGHI VCLNSVLALS AIPGAIDYCT SKASAFAFME SLTLGLLDCP GVSATTVLPF HTSTEMFQGM RVRFPNLFPP LKPETVARRT VEAVQLNQAL LLLPWTMHAL VILKSILPQA ALEEIHKFSG TYTCMNTFKG RT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards