About Diacylglycerol kinase iota
Diacylglycerol kinase iota (DGKI) is a protein
from Homo sapiens identified by UniProt accession
O75912, 1057 residues long.
MolForge cross-references it against 0 known binders and
76 disease associations.
Target properties
| Protein name | Diacylglycerol kinase iota |
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| UniProt accession | O75912 |
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| Gene | DGKI |
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| Organism | Homo sapiens |
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| Length | 1057 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (76)
Diseases linked to this target (Open Targets).
- body mass index · score 0.43
- body height · score 0.37
- neurodegenerative disease · score 0.32
- bronchitis · score 0.31
- drug use measurement · score 0.31
- breast adenocarcinoma · score 0.25
- schizophrenia · score 0.23
- cortical surface area measurement · score 0.23
- cortical thickness · score 0.21
- neuroimaging measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75912-F1 | alphafold | PREDICTED | 72.38 | — |
Amino-acid sequence (1057 residues)
MDAAGRGCHL LPLPAARGPA RAPAAAAAAA ASPPGPCSGA ACAPSAAAGA GAMNPSSSAG EEKGATGGSS SSGSGAGSCC LGAEGGADPR GAGSAAAAGA AALDEPAAAG QKEKDEALEE KLRNLTFRKQ VSYRKAISRA GLQHLAPAHP LSLPVANGPA KEPRATLDWS ENAVNGEHLW LETNVSGDLC YLGEENCQVR FAKSALRRKC AVCKIVVHTA CIEQLEKINF RCKPTFREGG SRSPRENFVR HHWVHRRRQE GKCKQCGKGF QQKFSFHSKE IVAISCSWCK QAFHNKVTCF MLHHIEEPCS LGAHAAVIVP PTWIIKVKKP QNSLKASNRK KKRTSFKRKA SKRGMEQENK GRPFVIKPIS SPLMKPLLVF VNPKSGGNQG TKVLQMFMWY LNPRQVFDLS QEGPKDALEL YRKVPNLRIL ACGGDGTVGW ILSILDELQL SPQPPVGVLP LGTGNDLART LNWGGGYTDE PVSKILCQVE DGTVVQLDRW NLHVERNPDL PPEELEDGVC KLPLNVFNNY FSLGFDAHVT LEFHESREAN PEKFNSRFRN KMFYAGAAFS DFLQRSSRDL SKHVKVVCDG TDLTPKIQEL KFQCIVFLNI PRYCAGTMPW GNPGDHHDFE PQRHDDGYIE VIGFTMASLA ALQVGGHGER LHQCREVMLL TYKSIPMQVD GEPCRLAPAM IRISLRNQAN MVQKSKRRTS MPLLNDPQSV PDRLRIRVNK ISLQDYEGFH YDKEKLREAS IPLGILVVRG DCDLETCRMY IDRLQEDLQS VSSGSQRVHY QDHETSFPRA LSAQRLSPRW CFLDATSADR FYRIDRSQEH LHFVMEISQD EIFILDPDMV VSQPAGTPPG MPDLVVEQAS GISDWWNPAL RKRMLSDSGL GMIAPYYEDS DLKDLSHSRV LQSPVSSEDH AILQAVIAGD LMKLIESYKN GGSLLIQGPD HCSLLHYAAK TGNGEIVKYI LDHGPSELLD MADSETGETA LHKAACQRNR AVCQLLVDAG ASLRKTDSKG KTPQERAQQA GDPDLAAYLE SRQNYKVIGH EDLETAV
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