About Serine/threonine-protein kinase PAK 3
Serine/threonine-protein kinase PAK 3 (PAK3) is a protein
from Homo sapiens identified by UniProt accession
O75914, 559 residues long.
MolForge cross-references it against 0 known binders and
60 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase PAK 3 |
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| UniProt accession | O75914 |
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| Gene | PAK3 |
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| Organism | Homo sapiens |
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| Length | 559 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (60)
Diseases linked to this target (Open Targets).
- X-linked non-syndromic intellectual disability · score 0.75
- Agenesis of corpus callosum · score 0.60
- Intellectual disability · score 0.43
- genetic disorder · score 0.41
- X-linked syndromic intellectual disability · score 0.37
- Microcephaly · score 0.34
- pancreatic adenocarcinoma · score 0.28
- thyroid gland adenocarcinoma · score 0.27
- breast adenocarcinoma · score 0.27
- endometrial cancer · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75914-F1 | alphafold | PREDICTED | 72.43 | — |
Amino-acid sequence (559 residues)
MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS IFPGGGDKTN KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTPDLYGSQM CPGKLPEGIP EQWARLLQTS NITKLEQKKN PQAVLDVLKF YDSKETVNNQ KYMSFTSGDK SAHGYIAAHP SSTKTASEPP LAPPVSEEED EEEEEEEDEN EPPPVIAPRP EHTKSIYTRS VVESIASPAV PNKEVTPPSA ENANSSTLYR NTDRQRKKSK MTDEEILEKL RSIVSVGDPK KKYTRFEKIG QGASGTVYTA LDIATGQEVA IKQMNLQQQP KKELIINEIL VMRENKNPNI VNYLDSYLVG DELWVVMEYL AGGSLTDVVT ETCMDEGQIA AVCRECLQAL DFLHSNQVIH RDIKSDNILL GMDGSVKLTD FGFCAQITPE QSKRSTMVGT PYWMAPEVVT RKAYGPKVDI WSLGIMAIEM VEGEPPYLNE NPLRALYLIA TNGTPELQNP ERLSAVFRDF LNRCLEMDVD RRGSAKELLQ HPFLKLAKPL SSLTPLIIAA KEAIKNSSR
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