About Regulator of G-protein signaling 9
Regulator of G-protein signaling 9 (RGS9) is a protein
from Homo sapiens identified by UniProt accession
O75916, 674 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Regulator of G-protein signaling 9 |
|---|
| UniProt accession | O75916 |
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| Gene | RGS9 |
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| Organism | Homo sapiens |
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| Length | 674 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- bradyopsia · score 0.59
- heel bone mineral density · score 0.38
- neurodegenerative disease · score 0.37
- Leber congenital amaurosis · score 0.33
- PHF-tau measurement · score 0.31
- bone quantitative ultrasound measurement · score 0.25
- ovarian cancer · score 0.25
- glioblastoma multiforme · score 0.25
- breast adenocarcinoma · score 0.24
- lung adenocarcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75916-F1 | alphafold | PREDICTED | 73.05 | — |
Amino-acid sequence (674 residues)
MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM TGSDVLQWIV QRLWISSLEA QNLGNFIVRY GYIYPLQDPK NLILKPDGSL YRFQTPYFWP TQQWPAEDTD YAIYLAKRNI KKKGILEEYE KENYNFLNQK MNYKWDFVIM QAKEQYRAGK ERNKADRYAL DCQEKAYWLV HRCPPGMDNV LDYGLDRVTN PNEVKVNQKQ TVVAVKKEIM YYQQALMRST VKSSVSLGGI VKYSEQFSSN DAIMSGCLPS NPWITDDTQF WDLNAKLVEI PTKMRVERWA FNFSELIRDP KGRQSFQYFL KKEFSGENLG FWEACEDLKY GDQSKVKEKA EEIYKLFLAP GARRWINIDG KTMDITVKGL KHPHRYVLDA AQTHIYMLMK KDSYARYLKS PIYKDMLAKA IEPQETTKKS STLPFMRRHL RSSPSPVILR QLEEEAKARE AANTVDITQP GQHMAPSPHL TVYTGTCMPP SPSSPFSSSC RSPRKPFASP SRFIRRPSTT ICPSPIRVAL ESSSGLEQKG ECSGSMAPRG PSVTESSEAS LDTSWPRSRP RAPPKARMAL SFSRFLRRGC LASPVFARLS PKCPAVSHGR VQPLGDVGQQ LPRLKSKRVA NFFQIKMDVP TGSGTCLMDS EDAGTGESGD RATEKEVICP WESL
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